口服补充高脂、高能量产品可改善囊性纤维化患者的营养状况并改变其血脂水平。
Oral supplementation with a high-fat, high-energy product improves nutritional status and alters serum lipids in patients with cystic fibrosis.
作者信息
Rettammel A L, Marcus M S, Farrell P M, Sondel S A, Koscik R E, Mischler E H
机构信息
Department of Nutritional Sciences, University of Wisconsin, Madison 53792-4108, USA.
出版信息
J Am Diet Assoc. 1995 Apr;95(4):454-9. doi: 10.1016/S0002-8223(95)00121-2.
OBJECTIVE
To assess the tolerance and acceptability of a nutrition supplement in patients with cystic fibrosis (CF), to monitor changes in dietary intake, and to evaluate nutritional status.
DESIGN
Subjects were their own controls for this 3-month, prospective, open study. Acceptability and tolerance questionnaires and 3-day food records were completed at baseline and monthly intervals. Compliance and nutritional status were also assessed.
SETTING
This study was conducted at the University of Wisconsin Hospital and Clinics Cystic Fibrosis Center, Madison.
SUBJECTS
Patients with CF older than 4 years of age were recruited during clinic or hospital visits if they met specific weight or growth criteria (n = 19).
INTERVENTION
Subjects were asked to consume the supplement at a maximum of 30% their estimated daily energy requirements.
MAIN OUTCOME MEASURES
Responses to acceptability ratings of and tolerance questions about the supplement were obtained along with anthropometric data and biochemical measurements of serum albumin, plasma retinol, alpha-tocopherol, and fatty acid levels.
STATISTICAL ANALYSES PERFORMED
Data were analyzed using Minitab and Statistical Analysis Software. Paired and unpaired t tests and nonparametric sign tests were used, as well as regression and Pearson correlations. A significance level of .05 was used for all tests.
RESULTS
All subjects tolerated the supplement, although 12 reported mild symptoms of fullness, nausea, and/or bloating, which were resolved when intake was distributed throughout the day. Mean compliance was 69% of recommended intake. Weight gain in children was strongly correlated with compliance (r = .98). Linoleic acid intake increased significantly (P = .0003) as did plasma linoleic acid in the phospholipid fraction (P = .03).
CONCLUSION
The supplement studied would be a beneficial addition to the supplementation choices available to patients with CF.
目的
评估营养补充剂在囊性纤维化（CF）患者中的耐受性和可接受性，监测饮食摄入量的变化，并评估营养状况。
设计
在这项为期3个月的前瞻性开放性研究中，受试者自身作为对照。在基线和每月间隔时完成可接受性和耐受性问卷以及3天食物记录。还评估了依从性和营养状况。
地点
本研究在麦迪逊市威斯康星大学医院及诊所囊性纤维化中心进行。
受试者
年龄大于4岁的CF患者，若符合特定体重或生长标准，则在门诊或住院期间招募（n = 19）。
干预
要求受试者摄入补充剂的量最多为其估计每日能量需求的30%。
主要观察指标
获得关于补充剂的可接受性评分和耐受性问题的回答，以及人体测量数据和血清白蛋白、血浆视黄醇、α-生育酚和脂肪酸水平的生化测量结果。
进行的统计分析
使用Minitab和统计分析软件对数据进行分析。使用配对和非配对t检验、非参数符号检验以及回归和Pearson相关性分析。所有检验的显著性水平均为0.05。
结果
所有受试者均耐受该补充剂，尽管有12人报告有轻度饱腹感、恶心和/或腹胀症状，当摄入量分散在一天中时这些症状得到缓解。平均依从性为推荐摄入量的69%。儿童体重增加与依从性密切相关（r = 0.98）。亚油酸摄入量显著增加（P = 0.0003），磷脂部分的血浆亚油酸也显著增加（P = 0.03）。
结论
所研究的补充剂将是CF患者现有补充选择中的有益补充。
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