人类T淋巴细胞上双T细胞受体β链的表达
Dual T cell receptor beta chain expression on human T lymphocytes.
作者信息
Davodeau F, Peyrat M A, Romagné F, Necker A, Hallet M M, Vié H, Bonneville M
机构信息
Institut National de la Santé et de la Recherche Médicale U211, Institut de Biologie, Nantes, France.
出版信息
J Exp Med. 1995 Apr 1;181(4):1391-8. doi: 10.1084/jem.181.4.1391.
Abstract
Allelic exclusion of lymphocyte antigen receptor chains has been hypothesized as a mechanism developed by the immune system to ensure efficient lymphocyte repertoire selection and tight control of lymphocyte specificity. It was effectively shown to be operative for both the immunoglobulin (Ig) and the T cell receptor (TCR) beta chain genes. Our present observations suggest that close to 1% of human T lymphocytes escape this allelic control, and express two surface TCR beta chains with distinct superantigenic reactivities. Since this high frequency of dual beta chain expressors did not result in any dramatic immune dysregulations, these results question the need for a mechanism ensuring clonal monospecificity through allelic exclusion.
摘要
淋巴细胞抗原受体链的等位基因排斥被假定为免疫系统发展出的一种机制，以确保有效的淋巴细胞库选择和对淋巴细胞特异性的严格控制。现已有效证明其对免疫球蛋白（Ig）和T细胞受体（TCR）β链基因均起作用。我们目前的观察结果表明，近1%的人类T淋巴细胞逃避了这种等位基因控制，并表达了两条具有不同超抗原反应性的表面TCRβ链。由于双β链表达细胞的这种高频率并未导致任何明显的免疫失调，这些结果对通过等位基因排斥确保克隆单特异性机制的必要性提出了质疑。
相似文献
1
Dual T cell receptor beta chain expression on human T lymphocytes.人类T淋巴细胞上双T细胞受体β链的表达
J Exp Med. 1995 Apr 1;181(4):1391-8. doi: 10.1084/jem.181.4.1391.
2
Normal T lymphocytes can express two different T cell receptor beta chains: implications for the mechanism of allelic exclusion.正常T淋巴细胞可表达两种不同的T细胞受体β链：对等位基因排斥机制的启示。
J Exp Med. 1995 Apr 1;181(4):1587-91. doi: 10.1084/jem.181.4.1587.
3
Surface expression of functional T cell receptor chains formed by interlocus recombination on human T lymphocytes.人T淋巴细胞上由基因座间重组形成的功能性T细胞受体链的表面表达。
J Exp Med. 1994 Nov 1;180(5):1685-91. doi: 10.1084/jem.180.5.1685.
4
T cell receptor V beta repertoire in mice lacking endogenous mouse mammary tumor provirus.缺乏内源性小鼠乳腺肿瘤病毒的小鼠中的T细胞受体Vβ谱系
Eur J Immunol. 1995 Mar;25(3):857-62. doi: 10.1002/eji.1830250334.
5
6
Increased frequency of 2,4,6-trinitrophenyl (TNP)-specific, H-2b-restricted cytotoxic T lymphocyte precursors in transgenic mice expressing a T cell receptor beta chain gene from an H-2b-restricted, TNP-specific cytolytic T cell clone.在表达来自H-2b限制性、2,4,6-三硝基苯基（TNP）特异性溶细胞性T细胞克隆的T细胞受体β链基因的转基因小鼠中，H-2b限制性、TNP特异性细胞毒性T淋巴细胞前体的频率增加。
Eur J Immunol. 1992 Feb;22(2):335-41. doi: 10.1002/eji.1830220208.
7
Allelic exclusion in pTalpha-deficient mice: no evidence for cell surface expression of two T cell receptor (TCR)-beta chains, but less efficient inhibition of endogeneous Vbeta--> (D)Jbeta rearrangements in the presence of a functional TCR-beta transgene.pTα缺陷小鼠中的等位基因排斥：没有证据表明两条T细胞受体（TCR）β链在细胞表面表达，但在存在功能性TCR-β转基因的情况下，对内源性Vβ→（D）Jβ重排的抑制效率较低。
J Exp Med. 1997 Aug 29;186(5):767-75. doi: 10.1084/jem.186.5.767.
8
T cells with dual antigen specificity in T cell receptor transgenic mice rejecting allografts.在排斥同种异体移植物的T细胞受体转基因小鼠中具有双重抗原特异性的T细胞。
Eur J Immunol. 1995 Oct;25(10):2813-7. doi: 10.1002/eji.1830251015.
9
Incomplete T cell receptor V beta allelic exclusion and dual V beta-expressing cells.不完全T细胞受体Vβ等位基因排斥与双表达Vβ细胞
J Immunol. 1995 Oct 1;155(7):3308-12.
10
T cell receptor (TCR) structure of autologous melanoma-reactive cytotoxic T lymphocyte (CTL) clones: tumor-infiltrating lymphocytes overexpress in vivo the TCR beta chain sequence used by an HLA-A2-restricted and melanocyte-lineage-specific CTL clone.自体黑色素瘤反应性细胞毒性T淋巴细胞（CTL）克隆的T细胞受体（TCR）结构：肿瘤浸润淋巴细胞在体内过度表达一种由HLA - A2限制性且黑色素细胞谱系特异性CTL克隆所使用的TCRβ链序列。
J Exp Med. 1993 Oct 1;178(4):1231-46. doi: 10.1084/jem.178.4.1231.
引用本文的文献
1
Mathematical Characterization of Private and Public Immune Receptor Sequences.免疫受体私有和公有序列的数学特征描述。
Bull Math Biol. 2023 Sep 14;85(10):102. doi: 10.1007/s11538-023-01190-z.
2
Molecular mimicry and autoimmunity in the time of COVID-19.在 COVID-19 时代的分子模拟和自身免疫。
J Autoimmun. 2023 Sep;139:103070. doi: 10.1016/j.jaut.2023.103070. Epub 2023 Jun 12.
3
Dual TCR-Expressing T Cells in Cancer: How Single-Cell Technologies Enable New Investigation.双 TCR 表达的 T 细胞在癌症中的作用：单细胞技术如何推动新的研究。
Immunohorizons. 2023 May 1;7(5):299-306. doi: 10.4049/immunohorizons.2200062.
4
Biomolecular Mechanisms of Autoimmune Diseases and Their Relationship with the Resident Microbiota: Friend or Foe?自身免疫性疾病的生物分子机制及其与常驻微生物群的关系：是友还是敌？
Pathophysiology. 2022 Sep 1;29(3):507-536. doi: 10.3390/pathophysiology29030041.
5
Th2 single-cell heterogeneity and clonal distribution at distant sites in helminth-infected mice.在感染蠕虫的小鼠中，Th2 单细胞异质性和远处部位的克隆分布。
Elife. 2022 Aug 11;11:e74183. doi: 10.7554/eLife.74183.
6
Monogenic TCRβ Assembly and Expression Are Paramount for Uniform Antigen Receptor Specificity of Individual αβ T Lymphocytes.单基因 TCRβ 组装和表达对于个体 αβ T 淋巴细胞的均匀抗原受体特异性至关重要。
J Immunol. 2022 Jul 1;209(1):93-98. doi: 10.4049/jimmunol.2200176. Epub 2022 Jun 13.
7
Genesis of the αβ T-cell receptor.αβ T 细胞受体的起源。
PLoS Comput Biol. 2019 Mar 4;15(3):e1006874. doi: 10.1371/journal.pcbi.1006874. eCollection 2019 Mar.
8
Humanized Mice Reveal New Insights Into the Thymic Selection of Human Autoreactive CD8 T Cells.人源化小鼠揭示人类自身反应性 CD8 T 细胞胸腺选择的新见解。
Front Immunol. 2019 Feb 4;10:63. doi: 10.3389/fimmu.2019.00063. eCollection 2019.
9
Dual TCR T Cells: Identity Crisis or Multitaskers?双 TCR T 细胞：身份危机还是多面手？
J Immunol. 2019 Feb 1;202(3):637-644. doi: 10.4049/jimmunol.1800904.
10
Cell of origin dictates aggression and stem cell number in acute lymphoblastic leukemia.急性淋巴细胞白血病的细胞起源决定侵袭性和干细胞数量。
Leukemia. 2018 Aug;32(8):1860-1865. doi: 10.1038/s41375-018-0130-0. Epub 2018 Apr 18.
本文引用的文献
1
Affinity maturation leads to differential expression of multiple copies of a kappa light-chain transgene.亲和力成熟导致κ轻链转基因多个拷贝的差异表达。
Nature. 1993 May 20;363(6426):271-3. doi: 10.1038/363271a0.
2
A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor beta chain and a 33 kd glycoprotein.前T细胞上一种新型的二硫键连接的异二聚体由T细胞受体β链和一种33kd的糖蛋白组成。
Cell. 1993 Oct 22;75(2):283-94. doi: 10.1016/0092-8674(93)80070-u.
3
Fine specificity of monoclonal antibodies directed at human T cell receptor variable regions: comparison with oligonucleotide-driven amplification for evaluation of V beta expression.针对人T细胞受体可变区的单克隆抗体的精细特异性：与寡核苷酸驱动扩增法比较以评估Vβ表达
Eur J Immunol. 1993 Jul;23(7):1422-9. doi: 10.1002/eji.1830230703.
4
Surface expression of two distinct functional antigen receptors on human gamma delta T cells.人类γδT细胞上两种不同功能抗原受体的表面表达。
Science. 1993 Jun 18;260(5115):1800-2. doi: 10.1126/science.8390096.
5
Peripheral selection of antigen receptor junctional features in a major human gamma delta subset.人类主要γδ亚群中抗原受体连接特征的外周选择
Eur J Immunol. 1993 Apr;23(4):804-8. doi: 10.1002/eji.1830230405.
6
Secretion of disulfide-linked human T-cell receptor gamma delta heterodimers.二硫键连接的人T细胞受体γδ异二聚体的分泌
J Biol Chem. 1993 Jul 25;268(21):15455-60.
7
Expression of two T cell receptor alpha chains: dual receptor T cells.两条T细胞受体α链的表达：双受体T细胞
Science. 1993 Oct 15;262(5132):422-4. doi: 10.1126/science.8211163.
8
Specificity and flexibility in thymic selection.胸腺选择中的特异性与灵活性。
Nature. 1994 Jun 30;369(6483):750-2. doi: 10.1038/369750a0.
9
Superantigens: bacterial and viral proteins that manipulate the immune system.超抗原：操控免疫系统的细菌和病毒蛋白。
Annu Rev Cell Biol. 1993;9:101-28. doi: 10.1146/annurev.cb.09.110193.000533.
10
Idiotype-like molecules on cells of a human T cell leukemia.人类T细胞白血病细胞上的类独特型分子。
J Exp Med. 1983 Sep 1;158(3):1000-5. doi: 10.1084/jem.158.3.1000.
Zotero 插件