氟罗沙星对480株医院分离菌的体外活性比较

Comparative in-vitro activity of fleroxacin against 480 nosocomial isolates.

作者信息

Sofianou D, Frantzidou F, Tsakris A

机构信息

Department of Medical Microbiology, Aristotelian University of Thessaloniki, Greece.

出版信息

J Chemother. 1994 Dec;6(6):399-403. doi: 10.1080/1120009x.1994.11741173.

DOI:10.1080/1120009x.1994.11741173

PMID:7699427

Abstract

A total of 480 recent clinical isolates were tested for their susceptibility to fleroxacin, norfloxacin, ofloxacin, gentamicin, piperacillin, cefoxitin, cefotaxime and imipenem. Fleroxacin showed potent activity against strains of Enterobacteriaceae, Acinetobacter spp. and gentamicin-sensitive Pseudomonas aeruginosa with MIC90s ranging from 0.06 to 2 mg/l, although the MIC90 for gentamicin-resistant P. aeruginosa strains was as high as 32 mg/l. The drug exhibited excellent activity against staphylococci, both methicillin-sensitive and -resistant. The overall activity of fleroxacin was comparable with that of norfloxacin and ofloxacin and higher than that exhibited by gentamicin and beta-lactam antibiotics tested.

摘要

共对480株近期临床分离菌进行了氟罗沙星、诺氟沙星、氧氟沙星、庆大霉素、哌拉西林、头孢西丁、头孢噻肟和亚胺培南的药敏试验。氟罗沙星对肠杆菌科细菌、不动杆菌属和对庆大霉素敏感的铜绿假单胞菌菌株显示出强大的活性，其MIC90范围为0.06至2mg/L，尽管对庆大霉素耐药的铜绿假单胞菌菌株的MIC90高达32mg/L。该药物对甲氧西林敏感和耐药的葡萄球菌均表现出优异的活性。氟罗沙星的总体活性与诺氟沙星和氧氟沙星相当，高于所测试的庆大霉素和β-内酰胺类抗生素。