Kinney D K, Levy D L, Yurgelun-Todd D A, Medoff D, LaJonchere C M, Radford-Paregol M
Laboratories for Psychiatric Research, McLean Hospital, Belmont, Massachusetts 02178.
J Psychiatr Res. 1994 Nov-Dec;28(6):499-509. doi: 10.1016/0022-3956(94)90040-x.
Many studies indicate that both obstetrical complications (OCs) and birth in winter or early spring are risk factors for schizophrenia, but few studies have examined how these risk factors covary in the same subjects. We assessed pre- and perinatal OCs, while blind to diagnosis, using medical data recorded at the time of subjects' births, in 29 probands with DSM-III schizophrenia or schizoaffective disorder and 39 of their unaffected adult sibs. Pre- and perinatal OCs were both significantly more common in probands than sibs. Schizophrenics not born during the winter or early spring had significantly more total and perinatal OCs than schizophrenics born in other months, but did not differ for prenatal OCs. Results indicate that OCs increase risk for schizophrenia, but also suggest the possibility that the impact of OCs on this risk may be affected by season of birth.
许多研究表明，产科并发症（OCs）以及在冬季或早春出生都是精神分裂症的风险因素，但很少有研究探讨这些风险因素在同一受试者中是如何共同变化的。我们利用受试者出生时记录的医疗数据，在29名符合《精神疾病诊断与统计手册》第三版（DSM-III）精神分裂症或分裂情感性障碍诊断标准的先证者及其39名未受影响的成年同胞中，在对诊断不知情的情况下评估产前和围产期的产科并发症。产前和围产期的产科并发症在先证者中都比在同胞中显著更常见。非冬季或早春出生的精神分裂症患者的产科并发症总数和围产期并发症明显多于其他月份出生的精神分裂症患者，但产前并发症没有差异。结果表明，产科并发症会增加患精神分裂症的风险，但也表明产科并发症对该风险的影响可能受出生季节影响。
