Harding J W, Wright J W, Swanson G N, Hanesworth J M, Krebs L T
Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman.
Kidney Int. 1994 Dec;46(6):1510-2. doi: 10.1038/ki.1994.432.
The AT4 receptor specifically binds Angiotensin (Ang) IV and is distinct from the AT1 and AT2 receptors which bind Ang II and Ang III. The AT4 receptor in bovine adrenal cortex has a Kd of 0.74 +/- 0.14 nM and a Bmax of 3.82 +/- 1.12 pmol/mg prot. Competition curves demonstrated the following rank order of affinity: Ang IV >> Ang III >> d-Arg - Ang II >> Sar1,Ile8 - Ang II = Ang II = Ang II (1-7) >> DuP753 = CGP42112A = PD 123177. AT4 receptors were present in many tissues from several mammalian species including human and monkey. AT4 and AT1/AT2 receptors revealed a differential distribution in the rat kidney.
AT4受体特异性结合血管紧张素（Ang）IV，与结合Ang II和Ang III的AT1和AT2受体不同。牛肾上腺皮质中的AT4受体解离常数（Kd）为0.74±0.14 nM，最大结合容量（Bmax）为3.82±1.12 pmol/mg蛋白。竞争曲线表明亲和力的排序如下：Ang IV >> Ang III >> d-精氨酸 - Ang II >> Sar1，Ile8 - Ang II = Ang II = Ang II（1 - 7）>> DuP753 = CGP42112A = PD 123177。AT4受体存在于包括人类和猴子在内的多种哺乳动物的许多组织中。AT4和AT1/AT2受体在大鼠肾脏中呈现出不同的分布。
