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血管紧张素 II 及其受体 1 和 2——细胞生物学中的多功能系统,我们了解多少?

Angiotensin II and Angiotensin Receptors 1 and 2-Multifunctional System in Cells Biology, What Do We Know?

机构信息

Department of Cell Culture and Genomic Analysis, Medical University of Lodz, Zeligowskiego 7/9, 90-752 Lodz, Poland.

出版信息

Cells. 2021 Feb 12;10(2):381. doi: 10.3390/cells10020381.

Abstract

For years, the renin-angiotensin system (RAS) has been perceived as a system whose role is to primarily modulate the functioning of the cardiovascular system. Years of research into the role of RAS have provided the necessary data to confirm that the role of RAS is very complex and not limited to the cardiovascular system. The presence of individual elements of the renin-angiotensin (RA) system allows to control many processes, ranging from the memorization to pro-cancer processes. Maintaining the proportions between the individual axes of the RA system allows for achieving a balance, often called homeostasis. Thus, any disturbance in the expression or activity of individual RAS elements leads to pathophysiological processes.

摘要

多年来,肾素-血管紧张素系统(RAS)一直被认为是主要调节心血管系统功能的系统。多年来对 RAS 作用的研究提供了必要的数据,证实了 RAS 的作用非常复杂,不仅限于心血管系统。肾素-血管紧张素(RA)系统各个元素的存在使得可以控制许多过程,从记忆到促癌过程。保持 RA 系统各个轴之间的比例可以达到平衡,通常称为体内平衡。因此,RA 系统各个元素的表达或活性的任何干扰都会导致病理生理过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1717/7917773/a1fa42fb5015/cells-10-00381-g001.jpg

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