Norden C W
Clin Orthop Relat Res. 1976 Jan-Feb(114):203-6.
Antimicrobial prophylaxis, to reduce the incidence of postoperative infections, has been a controversial subject. The administration of antibiotics just prior to and up to 3 hours after operation has been demonstrated to be effective in preventing experimental staphylococcal wound infection in animals. However, the use of prophylactic antibiotics in orthopedic surgery has been tested in appropriate clinical trials only in the treatment of fractured hip. In that setting, prophylactic antibiotics were found to be efficacious. Although used extensively in other procedures such as total hip replacement, statistically valid evidence of the efficacy of prophylactic antibiotics has not been produced. Suggestions are offered for the conduct of clinical trials to study this important question.
为降低术后感染发生率而进行的抗菌预防一直是个有争议的话题。在手术前及术后长达3小时使用抗生素已被证明对预防动物实验性葡萄球菌伤口感染有效。然而，预防性抗生素在骨科手术中的应用仅在髋部骨折治疗的适当临床试验中进行了测试。在那种情况下，发现预防性抗生素是有效的。尽管预防性抗生素在全髋关节置换等其他手术中被广泛使用，但尚未产生关于其疗效的统计学有效证据。本文针对研究这一重要问题的临床试验开展提出了建议。
