Ryzhenkov V E, Chistiakova A M, Frolova Iu V, Lozovskiĭ V T, Kameneva I Iu, Vasil'eva L E
Patol Fiziol Eksp Ter. 1994 Oct-Dec(4):33-6.
Models of experimental dyslipoproteinemias have been developed by using non-inbred rats (males and females) and guinea-pigs. Administration of cholesterol (C) with fats and supplementation of 4-hydroxy-6-methyl-2-thiouracil to male rats and that of C in the mixture of fats to guinea-pigs have been demonstrated to lead to the development of atherogenic dyslipoproteinemias. Genfibrozil, cholestyramine and vasosan II, a new pectin-enriched formulation, promoted normalization of the impaired serum lipoprotein spectrum caused by exogenous C administration. Bilateral ovariectomy in female rats induced atherogenic dyslipoproteinemia. The use of the estrogen derivative methyl ether of 6-oxa-D-homo-8-isoestrone normalized lipid and lipoprotein metabolic disturbances.
通过使用非近交系大鼠（雄性和雌性）和豚鼠建立了实验性血脂异常模型。已证明，给雄性大鼠喂食含脂肪的胆固醇（C）并补充4-羟基-6-甲基-2-硫尿嘧啶，以及给豚鼠喂食含C的脂肪混合物，会导致致动脉粥样硬化性血脂异常。吉非贝齐、考来烯胺和一种新的富含果胶的制剂Vasosan II，可促进外源性C给药引起的受损血清脂蛋白谱正常化。雌性大鼠双侧卵巢切除可诱发致动脉粥样硬化性血脂异常。使用雌激素衍生物6-氧杂-D-高-8-异雌酮甲醚可使脂质和脂蛋白代谢紊乱正常化。
