Jones C J
Curr Med Res Opin. 1976;4(1):3-16. doi: 10.1185/03007997609109277.
The pharmacology and pharmacokinetic properties of azapropazone, a new anti-inflammatory analgesic, are reviewed. Anti-inflammatory activity was assessed by standard in vivo and in vitro methods. The drug was shown to have definite activity with a potency approximately half that of phenylbutazone. Azapropazone was absorbed from the gastro-intestinal tract in animals and man, although wide inter-species variation in pharmacokinetic properties was noted. In man, the biological half life was approximately 20 hours. Azapropazone is not extensively metabolised and most metabolites have been identified and assayed.
对一种新型抗炎镇痛药阿扎丙宗的药理及药代动力学特性进行了综述。采用标准的体内和体外方法评估其抗炎活性。结果表明该药物具有明确的活性，效力约为保泰松的一半。阿扎丙宗可在动物和人体中从胃肠道吸收，不过药代动力学特性在不同物种间存在很大差异。在人体中，其生物半衰期约为20小时。阿扎丙宗代谢不广泛，且大多数代谢产物已被鉴定和测定。
