三新木脂素化合物 Trogopterins A-C：从中华鼯鼠粪便中分离得到。

Trogopterins A-C: Three new neolignans from feces of Trogopterus xanthipes.

机构信息

School of Biotechnology, Yeungnam University, Daedong, Gyeongsan, Gyeongbuk 712-749, South Korea.

Key Laboratory for Applied Microbiology of Shandong Province, Biotechnology Center of Shandong Academy of Sciences, Jinan 250014, P. R. China.

出版信息

Beilstein J Org Chem. 2014 Dec 11;10:2955-2962. doi: 10.3762/bjoc.10.313. eCollection 2014.

DOI:10.3762/bjoc.10.313

PMID:25550762

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4273270/

Abstract

Seven compounds, including three neolignans 1-3, a norlignan 4, and three diterpenoids 5-7, were isolated from the feces of Trogopterus xanthipes. Structures of these compounds were identified by 1D and 2D NMR as well as MS. The absolute configurations of compounds 1, 2, and 4 were determined by comparing CD spectra and optical rotations. Among the isolated compounds, 1-3 were novel and subsequently named trogopterins A, B, and C, respectively. Likewise, compound 4 was isolated from nature for the first time. Cytotoxic activities of compounds 1-4 were evaluated. Compounds 1-3 exhibited moderate cytotoxic activities against HL-60 cells with IC50 values of 34.77-45.68 μM.

摘要

从中华鼢鼠的粪便中分离得到了 7 种化合物，包括 3 种新木脂素 1-3、1 种去甲木脂素 4 和 3 种二萜 5-7。通过 1D 和 2D NMR 以及 MS 确定了这些化合物的结构。通过比较 CD 光谱和旋光度确定了化合物 1、2 和 4 的绝对构型。其中，化合物 1-3 为新化合物，分别命名为鼢鼠酮 A、B 和 C。同样，化合物 4 也是首次从自然界中分离得到的。对化合物 1-4 的细胞毒性进行了评价。化合物 1-3 对 HL-60 细胞表现出中等的细胞毒性，IC50 值为 34.77-45.68 μM。