Alves T M, Chaves P P, Santos L M, Nagem T J, Murta S M, Ceravolo I P, Romanha A J, Zani C L
Planta Med. 1995 Feb;61(1):85-7. doi: 10.1055/s-2006-958011.
The diterpene ent-kaur-16-en-19-oic acid (1) was identified as the trypanocidal component of the ethanolic extract from Mikania obtusata D. C. (Asteraceae). This compound presents an IC50 of 0.5 mg/ml (1.66 mM) against the trypomastigote blood form of the Trypanosoma cruzi, the causative agent of Chagas' disease (American trypanosomiasis).
二萜类化合物对映-贝壳杉-16-烯-19-酸（1）被鉴定为钝叶薇甘菊（菊科）乙醇提取物中的杀锥虫成分。该化合物对恰加斯病（美洲锥虫病）的病原体克氏锥虫的血液型锥鞭毛虫的半数抑制浓度（IC50）为0.5毫克/毫升（1.66毫摩尔）。
