Ribeiro A, Piló-Veloso D, Romanha A J, Zani C L
Departamento de Química-ICEx-UFMG, Belo Horizonte, MG, Brazil.
J Nat Prod. 1997 Aug;60(8):836-41. doi: 10.1021/np970196p.
The crude extract of Trixis vauthieri (Asteraceae) was active against the trypomastigote forms of Trypanosoma cruzi, the protozoan that causes Chagas' disease. Bioassay-guided fractionation of this extract afforded the trypanocidal flavonoids 5,4'-dihydroxy-7-methoxyflavanone (1) and 5,4'-dihydroxy-3,6,7-trimethoxyflavone (2) besides the inactive flavonoids 3,5,4'-trihydroxy-7-methoxyflavanone (3) and 5,4'-dihydroxy-3,6,7,8-tetramethoxy flavone (4). The trypanocidal activity of 1 and 2 and the presence of compounds 2 and 4 in Trixis vauthieri are reported here for the first time.
三齿叶菊（菊科）的粗提物对克氏锥虫的锥鞭毛体形式具有活性，克氏锥虫是引起恰加斯病的原生动物。对该提取物进行生物测定导向的分级分离，除了无活性的黄酮类化合物3,5,4'-三羟基-7-甲氧基黄烷酮（3）和5,4'-二羟基-3,6,7,8-四甲氧基黄酮（4）外，还得到了杀锥虫黄酮类化合物5,4'-二羟基-7-甲氧基黄烷酮（1）和5,4'-二羟基-3,6,7-三甲氧基黄酮（2）。本文首次报道了1和2的杀锥虫活性以及三齿叶菊中化合物2和4的存在情况。
