Myers B, Pueschel S M
Brown University School of Medicine, Rhode Island Hospital, Providence 02902, USA.
Res Dev Disabil. 1995 Jan-Feb;16(1):1-9. doi: 10.1016/0891-4222(94)00018-5.
In a population of 425 individuals with Down syndrome, we observed 5 persons (1.2%) with Tourette's disorder. Because the prevalence of Tourette's disorder in the general population has been estimated to be between 0.03% and 1.6%, it is not likely that there is an increased prevalence of Tourette's disorder in Down syndrome, or that there is an interrelationship between Down syndrome and Tourette's disorder. This lack of relationship argues against an atypical Tourette's disorder. The absence of family histories of Tourette's disorder in our patients, the relatively late onset of the disorder in most of our patients, their previous treatment with neuroleptic and psychostimulant medication, and the lack of relationship between Down syndrome and Tourette's disorder in this Down syndrome population are factors that support the diagnosis of tardive Tourette's disorder.
在425名唐氏综合征患者中，我们观察到5人（1.2%）患有图雷特氏症。由于据估计普通人群中图雷特氏症的患病率在0.03%至1.6%之间，因此唐氏综合征患者中图雷特氏症的患病率不太可能增加，唐氏综合征与图雷特氏症之间也不太可能存在相互关系。这种缺乏关联的情况反对将其诊断为非典型图雷特氏症。我们的患者中缺乏图雷特氏症家族史、大多数患者发病相对较晚、他们之前接受过抗精神病药物和精神兴奋药物治疗，以及在这个唐氏综合征人群中唐氏综合征与图雷特氏症之间缺乏关联，这些因素都支持迟发性图雷特氏症的诊断。
