Stewénius J, Adnerhill I, Ekelund G, Florén C H, Fork F T, Janzon L, Lindström C, Mars I, Nyman M, Rosengren J E
Dept. of Surgery, Malmö General Hospital, Sweden.
Scand J Gastroenterol. 1995 Jan;30(1):38-43. doi: 10.3109/00365529509093233.
This study was designed to assess time trends in the incidence of ulcerative colitis and indeterminate colitis in an urban population.
Medical records of in- and out-patients with inflammatory bowel disease were reviewed by a panel to establish the diagnosis. All histopathologic specimens and almost all radiographs were re-examined.
During the time period 1958 to 1982 there were 354 new cases of definite ulcerative colitis, 117 of probable ulcerative colitis, and 100 of indeterminate colitis. This corresponds to an average annual incidence per 100,000 of 5.5, 1.8, and 1.6, respectively. The incidence was higher in men than in women. Peak incidence was between 20 and 29 years, but indeterminate colitis was most common in 10- to 19-year-old males. The incidence was stable from 1958 to 1972 but then increased in almost all age groups in both sexes. The increase in annual incidence of definite ulcerative colitis from 4.2 to 9.4/10(5) corresponds to an average annual increase of about 5% (p < 0.001). The increase in the incidence of definite ulcerative colitis was due to an increased proportion of patients with proctitis.
This study has shown an increased incidence of ulcerative colitis and indeterminate colitis, and we have found no reason to believe that this is a spurious finding.
本研究旨在评估城市人群中溃疡性结肠炎和不确定性结肠炎发病率的时间趋势。
由一个专家小组审查炎症性肠病门诊和住院患者的病历以确立诊断。所有组织病理学标本和几乎所有的X光片都进行了重新检查。
在1958年至1982年期间，有354例确诊溃疡性结肠炎新病例，117例可能的溃疡性结肠炎病例和100例不确定性结肠炎病例。这分别对应每10万人中每年的平均发病率为5.5、1.8和1.6。男性发病率高于女性。发病高峰在20至29岁之间，但不确定性结肠炎在10至19岁男性中最为常见。1958年至1972年发病率稳定，但随后几乎所有年龄组的男性和女性发病率均有所上升。确诊溃疡性结肠炎的年发病率从4.2/10万增加到9.4/10万，平均每年增加约5%（p<0.001）。确诊溃疡性结肠炎发病率的增加是由于直肠炎患者比例增加。
本研究显示溃疡性结肠炎和不确定性结肠炎的发病率有所上升，我们没有理由认为这是一个虚假的发现。
