一种在马和人类中引发致命疾病的麻疹病毒。

A morbillivirus that caused fatal disease in horses and humans.

作者信息

Murray K, Selleck P, Hooper P, Hyatt A, Gould A, Gleeson L, Westbury H, Hiley L, Selvey L, Rodwell B

机构信息

CSIRO Australian Animal Health Laboratory, East Geelong, Victoria.

出版信息

Science. 1995 Apr 7;268(5207):94-7. doi: 10.1126/science.7701348.

DOI:10.1126/science.7701348

PMID:7701348

Abstract

A morbillivirus has been isolated and added to an increasing list of emerging viral diseases. This virus caused an outbreak of fatal respiratory disease in horses and humans. Genetic analyses show it to be only distantly related to the classic morbilliviruses rinderpest, measles, and canine distemper. When seen by electron microscopy, viruses had 10- and 18-nanometer surface projections that gave them a "double-fringed" appearance. The virus induced syncytia that developed in the endothelium of blood vessels, particularly the lungs.

摘要

一种麻疹病毒已被分离出来，这使得新出现的病毒性疾病名单不断增加。这种病毒在马和人类中引发了致命的呼吸道疾病疫情。基因分析表明，它与经典的麻疹病毒——牛瘟、麻疹和犬瘟热——仅有远亲关系。在电子显微镜下观察时，病毒有10纳米和18纳米的表面突起，使其呈现出“双边缘”外观。该病毒诱导血管内皮尤其是肺部形成多核巨细胞。