Selvey L A, Wells R M, McCormack J G, Ansford A J, Murray K, Rogers R J, Lavercombe P S, Selleck P, Sheridan J W
Communicable Diseases Branch, Queensland Health, Brisbane.
Med J Aust. 1995 Jun 19;162(12):642-5. doi: 10.5694/j.1326-5377.1995.tb126050.x.
To describe the clinical and epidemiological features of an outbreak of a viral infection affecting humans and horses.
Stables in Hendra, a suburb of Brisbane.
Affected horses and humans, and at-risk human contacts.
A pregnant mare died two days after arrival from a paddock elsewhere in Brisbane. Eight to 11 days later, illness (depression, anorexia, fever, dyspnoea, ataxia, tachycardia, tachypnoea and nasal discharge) was reported among 17 other horses from the same or an adjoining stable. Fourteen horses died or were put down. Five and six days after the index mare's death, a stable-hand and then a horse-trainer, both of whom had had close contact with the sick mare's mucous secretions, developed influenza-like illnesses. The stable-hand recovered but the trainer developed pneumonitis, respiratory failure, renal failure and arterial thrombosis, and died from a cardiac arrest seven days after admission to hospital. A morbillivirus cultured from his kidney was identical to one isolated from the lungs of five affected horses. The two affected humans and eight other horses were seropositive for the infection, which was reproduced in healthy horses following challenge by spleen/lung homogenates from infected horses. There was no serological evidence of infection in 157 humans who had had contact with the stables or the sick horses or humans.
A previously undescribed morbillivirus infected a probable 21 horses and two humans; one human and 14 horses died. That no further cases were detected among humans suggests that the virus was of low infectivity. The source of infection remains undetermined.
描述一起影响人类和马匹的病毒感染暴发的临床及流行病学特征。
布里斯班郊区亨德拉的马厩。
受影响的马匹和人类，以及有感染风险的人类接触者。
一匹怀孕母马从布里斯班其他地方的牧场抵达后两天死亡。8至11天后，同一马厩或相邻马厩的另外17匹马出现疾病（抑郁、厌食、发热、呼吸困难、共济失调、心动过速、呼吸急促和鼻腔分泌物增多）。14匹马死亡或被安乐死。在首例母马死亡后的第5天和第6天，一名马夫和一名驯马师先后出现流感样疾病，他们均与患病母马的黏液分泌物有过密切接触。马夫康复，但驯马师发展为肺炎、呼吸衰竭、肾衰竭和动脉血栓形成，入院7天后因心脏骤停死亡。从他肾脏培养出的一种麻疹病毒与从5匹患病马的肺部分离出的病毒相同。两名受感染的人类和另外8匹马对该感染呈血清学阳性，用感染马的脾脏/肺匀浆攻击健康马后可使其感染。157名与马厩或患病马匹或人类有过接触的人没有感染的血清学证据。
一种先前未描述的麻疹病毒感染了可能21匹马和两名人类；一名人类和14匹马死亡。在人类中未检测到更多病例表明该病毒传染性较低。感染源仍未确定。
