Kareem B A, Das P K, Saad R
Department of Orthopaedics, Hospital Universiti Sains Malaysia, Kelantan.
Singapore Med J. 1994 Oct;35(5):527-8.
Disappearing bone disease is a rare condition and usually affects young adults. Its aetiology is not known. A case of a 12-year-old female child, who had a fall and sustained a fracture mid shaft of femur and supracondylar region, is reported. On follow-up subsequent X-ray showed extensive osteolysis which was progressively affecting the other side of the pelvic girdle and femur. She was put on trial of calcitonin 50 IU by nasal spray for six months but there was no improvement. However, during the past three and half years the disease process had progressively extended to the other side of pelvic girdle and femur with fatal outcome. To the knowledge of the authors such progression in a short time has not been reported in any case so far.
骨质溶解症是一种罕见病症，通常影响年轻成年人。其病因尚不清楚。本文报告了一例12岁女童病例，该女童摔倒后导致股骨干中段和髁上区域骨折。随访时的后续X光检查显示广泛的骨质溶解，且逐渐影响到骨盆带和股骨的另一侧。她接受了为期六个月的鼻喷降钙素50国际单位的试验性治疗，但并无改善。然而，在过去三年半的时间里，疾病进程逐渐蔓延至骨盆带和股骨的另一侧，最终导致死亡。据作者所知，迄今为止尚未有任何病例报道过在短时间内出现如此进展的情况。
