Shives T C, Beabout J W, Unni K K
Mayo Clinic, Rochester, MN 55905.
Clin Orthop Relat Res. 1993 Sep(294):267-76.
Massive osteolysis is rare, peculiar, and enigmatic. The clinical, radiographic, and histologic features were reviewed in 11 cases. The patients were generally young (mean age, 20.7 years), and males outnumbered females. More than half the patients had involvement of either the femur or the ribs alone or including the vertebrae. On the basis of radiographic studies, the disease process is capable of originating either in bone or adjacent soft tissues. Histologically, the authors were unable to identify pathognomonic features. Other than excision of all involved tissue, surgical treatment was generally ineffective. Radiation therapy may be successful in eradicating the disease in selected cases.
巨大性骨溶解罕见、奇特且神秘莫测。对11例患者的临床、影像学及组织学特征进行了回顾性分析。患者一般较为年轻（平均年龄20.7岁），男性多于女性。半数以上患者单独累及股骨或肋骨，或包括椎体。基于影像学研究，该疾病过程可能起源于骨或邻近软组织。在组织学上，作者无法识别出具有诊断意义的特征。除切除所有受累组织外，手术治疗通常无效。在某些选定病例中，放射治疗可能成功根除该疾病。
