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本文引用的文献

1
Toxicity form rifampicin plus isoniazid and rifampicin plus ethambutol therapy.利福平加异烟肼及利福平加乙胺丁醇疗法的毒性。
Tubercle. 1971 Sep;52(3):182-90. doi: 10.1016/0041-3879(71)90041-9.
2
Rifampin-induced release of hydrazine from isoniazid. A possible cause of hepatitis during treatment of tuberculosis with regimens containing isoniazid and rifampin.利福平诱导异烟肼释放肼。含异烟肼和利福平方案治疗结核病期间肝炎的一个可能原因。
Am Rev Respir Dis. 1986 Jun;133(6):1072-5. doi: 10.1164/arrd.1986.133.6.1072.
3
Drug-induced liver disease.
Med Clin North Am. 1989 Jul;73(4):775-92. doi: 10.1016/s0025-7125(16)30638-1.
4
Toxic hepatitis with isoniazid and rifampin. A meta-analysis.
Chest. 1991 Feb;99(2):465-71. doi: 10.1378/chest.99.2.465.
5
Isoniazid-related hepatitis: a U.S. Public Health Service cooperative surveillance study.异烟肼相关性肝炎：一项美国公共卫生服务合作监测研究。
Am Rev Respir Dis. 1978 Jun;117(6):991-1001. doi: 10.1164/arrd.1978.117.6.991.

异烟肼和利福平联合作用引起的肝毒性。

Hepatotoxicity caused by the combined action of isoniazid and rifampicin.

作者信息

Askgaard D S, Wilcke T, Døssing M

机构信息

Medical Department P, Bispebjerg Hospital, Copenhagen, Denmark.

出版信息

Thorax. 1995 Feb;50(2):213-4. doi: 10.1136/thx.50.2.213.

DOI:10.1136/thx.50.2.213
PMID:7701468
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC473930/
Abstract

A 35 year old black Somalian woman with miliary tuberculosis developed hepatotoxicity after a few days of treatment with isoniazid, rifampicin, pyrazinamide, and ethambutol. After withdrawal of all drugs the liver profile returned to normal and remained so after challenge with isoniazid. Hepatotoxicity recurred when rifampicin was added, but it was well tolerated when reintroduced without isoniazid.

摘要

一名35岁的索马里黑人女性患有粟粒性肺结核，在接受异烟肼、利福平、吡嗪酰胺和乙胺丁醇治疗几天后出现肝毒性。停用所有药物后，肝功能检查恢复正常，再次使用异烟肼进行激发试验后仍保持正常。添加利福平时肝毒性复发，但在不使用异烟肼的情况下重新引入利福平时耐受性良好。