Ekelund B, Ladefoged S D, Kverneland A
Nefrologisk afdeling, Hvidovre Hospital, København.
Ugeskr Laeger. 1995 Feb 27;157(9):1176-8.
A urea kinetic analysis, (the Sargent and Gotch model), was applied to 62 haemodialysis patients. The protein catabolic rate was below 1 g/kg/day in 56.5% of the patients and 66.3% had a KT/V (Clearance x Time/Volume) below 1. The median KT/V was 0.90 and the median normalized protein catabolic rate was 0.95 g/kg/day. KT/V was strongly correlated to protein intake (normalized protein catabolic rate). It is concluded that urea kinetic modelling is a practical tool for assessing the dialysis adequacy and nutritional status of haemodialyzed patients.
对62例血液透析患者进行了尿素动力学分析（萨金特和戈奇模型）。56.5%的患者蛋白质分解代谢率低于1克/千克/天，66.3%的患者KT/V（清除率×时间/体积）低于1。KT/V中位数为0.90，标准化蛋白质分解代谢率中位数为0.95克/千克/天。KT/V与蛋白质摄入量（标准化蛋白质分解代谢率）密切相关。得出结论，尿素动力学建模是评估血液透析患者透析充分性和营养状况的实用工具。
