Bottomley W, Goodfield M
Department of Dermatology, Leeds General Infirmary, UK.
Acta Derm Venereol. 1994 Nov;74(6):433-4. doi: 10.2340/0001555574433434.
Plasma endothelin response to a standardized cold challenge in 7 patients with primary Raynaud's phenomenon and 7 controls using a sensitive radioimmunoassay was measured. There was no difference between resting levels of plasma endothelin in patients with primary Raynaud's phenomenon (2.6 fmol/ml) and controls (2.4 fmol/ml). A decrease in plasma endothelin levels in both groups of patients during the initial phase of the cold challenge was detected; this was more pronounced in the patients with Raynaud's phenomenon. These results suggest that there is no persistent stimulus to overproduction of endothelin. The fall in levels in patients with Raynaud's phenomenon during the initial phase of the cold challenge might suggest that a different vasoconstrictive factor is initiating the start of the vasospastic process, with the decreased endothelin levels being a reactive response to increased vasoconstriction produced by this alternative factor.
采用灵敏的放射免疫分析法，测定了7例原发性雷诺现象患者和7例对照者对标准化冷刺激的血浆内皮素反应。原发性雷诺现象患者的静息血浆内皮素水平（2.6 fmol/ml）与对照者（2.4 fmol/ml）之间无差异。在冷刺激初始阶段，两组患者的血浆内皮素水平均下降；在雷诺现象患者中更为明显。这些结果表明，不存在持续刺激内皮素过度产生的因素。在冷刺激初始阶段，雷诺现象患者内皮素水平下降可能提示，一种不同的血管收缩因子启动了血管痉挛过程，内皮素水平降低是对该替代因子产生的血管收缩增强的一种反应性应答。
