Val-Bernal J F, Corral J, Fernández F, Gómez-Bellvert C
Department of Pathology, University Hospital Marqués de Valdecilla, Faculty of Medicine, University of Cantabria, Santander, Spain.
Acta Derm Venereol. 1994 Nov;74(6):467-70. doi: 10.2340/0001555574467470.
Atypical fibroxanthoma has a wide spectrum of histological appearances. A variant recently described is atypical fibroxanthoma with osteoclast-like giant cells. One case of this rare tumour is described. The tumour arose on the forehead of an 87-year-old woman in the form of a subepidermal nodule. The lesion was incompletely excised and recurred 6 months later without showing any characteristics of aggression. Six months after the second operation the patient was well and showed no signs of tumour recurrence. Immunohistological findings showed a "fibrohistiocytic" profile and were similar to those observed in other lesions rich in osteoclast-like giant cells. Flow cytometry revealed the diploid nature of the primary and the recurrent tumour. Atypical fibroxanthoma with osteoclast-like giant cells is a new variant of atypical fibroxanthoma that must be recognized by pathologists, since it can be confused with other benign and malignant tumours with a high proportion of multinucleate osteoclast-like giant cells.
非典型纤维黄色瘤具有广泛的组织学表现。最近描述的一种变异型是非典型纤维黄色瘤伴破骨细胞样巨细胞。本文报道了1例这种罕见肿瘤。该肿瘤发生于一名87岁女性的前额，表现为表皮下结节。病变切除不完全，6个月后复发，未表现出任何侵袭性特征。第二次手术后6个月，患者情况良好，未出现肿瘤复发迹象。免疫组织学检查结果显示为“纤维组织细胞”特征，与在其他富含破骨细胞样巨细胞的病变中观察到的结果相似。流式细胞术显示原发肿瘤和复发肿瘤均为二倍体性质。非典型纤维黄色瘤伴破骨细胞样巨细胞是非典型纤维黄色瘤的一种新变异型，病理学家必须认识到这一点，因为它可能与其他含有高比例多核破骨细胞样巨细胞的良性和恶性肿瘤相混淆。
