Paolisso G, Gambardella A, Giugliano D, Galzerano D, Amato L, Volpe C, Balbi V, Varricchio M, D'Onofrio F
Department of Geriatric Medicine and Metabolic Diseases, II, University of Naples, Italy.
Am J Clin Nutr. 1995 Apr;61(4):848-52. doi: 10.1093/ajcn/61.4.848.
Thirty elderly (mean +/- SEM: 73.8 +/- 2.1 y) nondiabetic, moderately obese (body mass index = 28.3 +/- 0.6 kg/m2) patients with stable effort angina underwent an oral-glucose-tolerance test and a euglycemic hyperinsulinemic glucose clamp before and after vitamin E supplementation (900 mg/d for 4 mo). The study was of a randomized, placebo-controlled, double-blind, and crossover design. Anthropometric indexes were stable throughout the study. Despite similar fasting and 2-h plasma glucose concentrations, vitamin E administration (compared with placebo) lowered fasting (88 +/- 14 and 68 +/- 9 pmol/L, P < 0.02) and 2-h (348 +/- 43 and 263 +/- 28 pmol/L, P < 0.05) plasma insulin concentrations, plasma triglyceride concentrations (1.34 +/- 0.06 and 1.07 +/- 0.03 mmol/L, P < 0.05), and the ratio of plasma LDL to HDL cholesterol (7.64 +/- 0.31 and 5.52 +/- 0.38, P < 0.02). Vitamin E administration was associated with higher nonoxidative glucose metabolism (18.1 +/- 0.5 and 10.6 +/- 0.7 mumol.kg lean body mass-1.min-1, P < 0.03) than was placebo administration during the euglycemic glucose clamp. We conclude that chronic intake of pharmacological doses of vitamin E might be useful in the therapy of elderly insulin-resistant patients with coronary heart disease.
30名老年（平均±标准误：73.8±2.1岁）非糖尿病、中度肥胖（体重指数=28.3±0.6kg/m2）且患有稳定型劳力性心绞痛的患者，在补充维生素E（900mg/d，共4个月）前后进行了口服葡萄糖耐量试验和正常血糖高胰岛素葡萄糖钳夹试验。该研究采用随机、安慰剂对照、双盲和交叉设计。在整个研究过程中人体测量指标保持稳定。尽管空腹和2小时血浆葡萄糖浓度相似，但补充维生素E（与安慰剂相比）降低了空腹（88±14和68±9pmol/L，P<0.02）和2小时（348±43和263±28pmol/L，P<0.05）血浆胰岛素浓度、血浆甘油三酯浓度（1.34±0.06和1.07±0.03mmol/L，P<0.05）以及血浆低密度脂蛋白与高密度脂蛋白胆固醇的比值（7.64±0.31和5.52±0.38，P<0.02）。在正常血糖葡萄糖钳夹试验期间，补充维生素E比补充安慰剂具有更高的非氧化葡萄糖代谢水平（18.1±0.5和10.6±0.7μmol·kg去脂体重-1·min-1，P<0.03）。我们得出结论，长期摄入药理剂量的维生素E可能对老年胰岛素抵抗性冠心病患者的治疗有益。
