Paolisso G, Di Maro G, Galzerano D, Cacciapuoti F, Varricchio G, Varricchio M, D'Onofrio F
Department of Geriatric Medicine and Metabolic Diseases, II University of Naples, Italy.
Am J Clin Nutr. 1994 Jun;59(6):1291-6. doi: 10.1093/ajcn/59.6.1291.
Twenty elderly (77 +/- 0.4 y), nonobese [body mass index (in kg/m2) 26.4 +/- 0.5] subjects with normal glucose tolerance were submitted to a euglycemic hyperinsulinemic (3.5 pmol.min/kg) glucose clamp in a double-blind, crossover, randomized procedure after 4 mo treatment with either vitamin E (900 mg d-alpha-tocopherol/d, Ephynal; Roche, Milan, Italy) or placebo. Body mass index was practically unchanged throughout the study. After the glucose clamp, insulin-mediated stimulation 2 of whole-body glucose disposal (18.4 +/- 0.5 vs 26.1 +/- 0.6 mumol.min/kg lean body mass P < 0.02) was significantly potentiated by vitamin E rather than placebo administration. Furthermore, net changes in plasma vitamin E concentrations correlated with net changes in insulin-stimulated whole-body glucose disposal (r = 0.60 P < 0.003). Plasma vitamin E concentrations seem to play an important role in the modulation of insulin action in elderly people.
20名糖耐量正常的老年受试者（77±0.4岁），非肥胖[体重指数（kg/m2）为26.4±0.5]，在接受维生素E（900mg d-α-生育酚/天，Ephynal；罗氏公司，意大利米兰）或安慰剂治疗4个月后，采用双盲、交叉、随机程序进行正常血糖高胰岛素血症（3.5pmol·min/kg）葡萄糖钳夹试验。在整个研究过程中，体重指数基本保持不变。葡萄糖钳夹试验后，维生素E而非安慰剂给药显著增强了胰岛素介导的全身葡萄糖处置刺激（18.4±0.5对26.1±0.6μmol·min/kg去脂体重，P<0.02）。此外，血浆维生素E浓度的净变化与胰岛素刺激的全身葡萄糖处置的净变化相关（r=0.60，P<0.003）。血浆维生素E浓度似乎在调节老年人胰岛素作用中起重要作用。
