乳糖酶根皮苷水解酶（LCT）基因定位于猪的15号染色体q13区域。

The lactase phlorizin hydrolase (LCT) gene maps to pig chromosome 15q13.

作者信息

Thomsen P D, Johansson M, Troelsen J T, Andersson L

机构信息

Department of Anatomy and Physiology, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.

出版信息

Anim Genet. 1995 Feb;26(1):49-52. doi: 10.1111/j.1365-2052.1995.tb02621.x.

DOI:10.1111/j.1365-2052.1995.tb02621.x

PMID:7702213

Abstract

A porcine 17kb genomic fragment was used as probe to map the lactase phlorizin hydrolase (LCT) gene to pig chromosome 15q13 by fluorescence in situ hybridization. Further, a three-allele TaqI RFLP was used to add the LCT gene to the proximal end of the chromosome 15 linkage map. Comparison of the human chromosome 2 gene map and the gene map of pig chromosome 15 indicates that the part of human chromosome 2 distal to the q13 band is homologous to pig chromosome 15.

摘要

使用一个猪的17kb基因组片段作为探针，通过荧光原位杂交将乳糖酶-根皮苷水解酶（LCT）基因定位到猪的15号染色体q13区域。此外，利用一个三等位基因的TaqI限制性片段长度多态性（RFLP）将LCT基因添加到15号染色体连锁图谱的近端。比较人类2号染色体基因图谱和猪15号染色体基因图谱表明，人类2号染色体q13带远端的部分与猪15号染色体同源。