Ferrarini P L, Mori C, Armani G, Rossi L
Dipartimento di Scienze Farmaceutiche, Università di Pisa.
Farmaco. 1995 Jan;50(1):69-72.
Synthesis of some 4H-pyrido[1,2-a]pyrimidin-4-ones and assay of their antibacterial and antifungal activity are reported. Compounds 3a-e,g were prepared by reaction of substituted 2-chloromethyl-4H-pyrido[1,2-a]pyrimidin-4-ones 2a-c with suitable amines. These compounds and the previously obtained analogues 5a-o and 6a,b have been tested for their antimicrobial activity. All tested compounds were devoid of antimicrobial activity.
报道了一些4H-吡啶并[1,2-a]嘧啶-4-酮的合成及其抗菌和抗真菌活性测定。化合物3a-e、g是通过取代的2-氯甲基-4H-吡啶并[1,2-a]嘧啶-4-酮2a-c与合适的胺反应制备的。已对这些化合物以及先前获得的类似物5a-o和6a、b进行了抗菌活性测试。所有测试化合物均无抗菌活性。
