Yin X J, Liu J Z, Li Y S, Kong X H, Liu H
Department of Environmental Health, Capital University of Medical Sciences, Beijing, China.
Biomed Environ Sci. 1994 Dec;7(4):346-56.
Methylene chloride extracts of particulates from liquefied petroleum gas (LPG) combustion appliance were studied by using Ames test, micronucleus test and inducibility of pulmonary and hepatic aryl hydrocarbon hydroxylase (AHH) and glutathione S-transferase (GST) in rats. The extracts showed mutagenicity for Salmonella typhimurium strain TA98 and its derivatives TA98NR and TA98/1,8-DNP6 with or without S9 mix. The revertants in strains TA98NR and TA98/1,8-DNP6 were less than 40% and 50% of that in strain TA98 without S9 mix, respectively. Positive results were obtained in mouse bone marrow micronucleus assay. Intratracheal instillation of the extracts led to increase in pulmonary (but not hepatic) AHH and GST activities in rats. It was seen that AHH was more sensitive than GST to induction by the extracts.
采用Ames试验、微核试验以及检测大鼠肺和肝芳烃羟化酶（AHH）和谷胱甘肽S - 转移酶（GST）的诱导活性，对液化石油气（LPG）燃烧器具颗粒物的二氯甲烷提取物进行了研究。该提取物对鼠伤寒沙门氏菌TA98菌株及其衍生物TA98NR和TA98/1,8 - DNP6，无论有无S9混合液均表现出致突变性。在无S9混合液时，TA98NR和TA98/1,8 - DNP6菌株的回复突变率分别低于TA98菌株的40%和50%。小鼠骨髓微核试验获得阳性结果。气管内滴注提取物导致大鼠肺（而非肝）AHH和GST活性增加。可见，提取物对AHH的诱导作用比GST更敏感。
