Péchadre J C, Sauvezie B, Osier C, Gibert J
Rev Electroencephalogr Neurophysiol Clin. 1977 Oct-Dec;7(4):443-7. doi: 10.1016/s0370-4475(77)80049-x.
The authors have treated 10 children presenting with severe epilepsy with repeated large doses of gamma-globulin. They noted a marked improvement in 7 of the children with respect to behaviour and a disappearance of seizures in 8 with comparable EEG improvement. Four children have been able to reduce their conventional anticonvulsant therapy considerably and 2 others havers received no other medication at all for 8 months. The possibility of an immune disturbance in some childhood epilepsies is thus suggested.
作者用大剂量反复注射γ-球蛋白治疗了10例患有严重癫痫的儿童。他们注意到,7名儿童的行为有显著改善,8名儿童的癫痫发作消失,脑电图也有相应改善。4名儿童能够大幅减少常规抗惊厥药物治疗,另外2名儿童在8个月内完全未服用其他药物。因此提示在某些儿童癫痫中可能存在免疫紊乱。