1,25-二羟维生素D3调节星形胶质细胞中NT-3、NT-4的mRNA表达，但不调节脑源性神经营养因子（BDNF）的mRNA表达。
1,25-dihydroxyvitamin D3 regulates NT-3, NT-4 but not BDNF mRNA in astrocytes.
作者信息
Neveu I, Naveilhan P, Baudet C, Brachet P, Metsis M
机构信息
Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
出版信息
Neuroreport. 1994 Dec 30;6(1):124-6. doi: 10.1097/00001756-199412300-00032.
The effect of 1,25-dihydroxyvitamin D3 on neurotrophin mRNA expression was studied in primary cultures of astrocytes. In addition to its known effects on NGF expression, 1,25-dihydroxyvitamin D3 was shown to upregulate NT-3 mRNA levels, while NT-4 expression was slightly but significantly downregulated. No effect was observed on BDNF mRNA expression. These data clearly show a differential regulation of the four neurotrophins by 1,25-dihydroxyvitamin D3 in primary cultures of astrocytes and suggest that 1,25-dihydroxyvitamin D3 may participate in the expression of NGF, NT-3 and NT-4 in the central nervous system.
在星形胶质细胞原代培养物中研究了1,25 - 二羟基维生素D3对神经营养因子mRNA表达的影响。除了其对NGF表达的已知作用外，1,25 - 二羟基维生素D3还被证明可上调NT - 3 mRNA水平，而NT - 4表达则轻微但显著下调。未观察到对BDNF mRNA表达有影响。这些数据清楚地表明，在星形胶质细胞原代培养物中，1,25 - 二羟基维生素D3对四种神经营养因子具有差异性调节作用，并提示1,25 - 二羟基维生素D3可能参与中枢神经系统中NGF、NT - 3和NT - 4的表达。
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