Xu J D, Liu Z H, Chen S Z
Dept. of Physiology, Chengde Medical College, Hebei.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1994 Nov;14(11):673-4.
In order to study the effects of Paeonia-Glycyrrhiza decoction (PGD) on the changes induced by cisplatin in rats, platinum-wire bipolar electrodes were inserted into the serosal membrane of the small intestine and migrating myoelectric complex (MMC) was used as index. After intravenous injection of cisplatin at doses of 4 mg/kg, the duration of the MMC cycles was significantly shorter than that of normal MMC cycles (P < 0.05) while the duration of phase III was remarkably prolonged comparing with that of normal phase III (P < 0.01) with latent period of 53.2 +/- 20.4 minutes. Taking PGD orally, cisplatin no longer induced the changes of MMC. The results suggest that PGD has marked adjusting effects on the changes of MMC induced by cisplatin. This might be one of the causes of PGD in relieving diarrhea induced by cisplatin in rats.
为研究芍药甘草汤（PGD）对顺铂诱导大鼠产生的变化的影响，将铂丝双极电极插入小肠浆膜，并以移行性复合肌电（MMC）作为指标。静脉注射4mg/kg顺铂后，MMC周期的持续时间显著短于正常MMC周期（P<0.05），而Ⅲ期的持续时间与正常Ⅲ期相比显著延长（P<0.01），潜伏期为53.2±20.4分钟。口服PGD后，顺铂不再诱导MMC的变化。结果表明，PGD对顺铂诱导的MMC变化具有显著的调节作用。这可能是PGD缓解大鼠顺铂诱导腹泻的原因之一。
