Goncharuk V D
L. A. Myasnikov-Institute of Clinical Cardiology, Russian Academy of Medical Sciences, Moscow.
Exp Toxicol Pathol. 1994 Dec;46(6):457-64. doi: 10.1016/S0940-2993(11)80061-8.
Cell bodies of cardio-vascular receptors localized in the ganglion nodosum of rabbits exposed to experimental emotional stress were studied with the light and electron microscope and histochemically. Under emotional stress some rabbits demonstrated almost unchanged arterial pressure and only a small increase in heart rate, while other animals displayed strongly marked disturbances of their blood circulation leading to the acute heart deficiency at the end of the experiment. In the stress-resistant rabbits, microscopic anatomy and ultrastructure of neurons indicated their increased activity. Activities of lysosomal enzymes--acid phosphatase and aminopeptidase--were found to be at the control level, while the activity of mitochondrial enzyme--glutamate dehydrogenase--was slightly increased. On the other hand morphological evidence of severe hyperactivity and exhaustion was revealed in neurons of the stress-predisposed rabbits. Moreover the activities of all three enzymes studied were significantly increased. These results indicate correlation between the structural and metabolic changes occurring under experimental emotional stress in nodosal neurons and the extent of hemodynamic changes.
利用光学显微镜、电子显微镜及组织化学方法，对处于实验性情绪应激状态下的家兔结节神经节内心血管受体的细胞体进行了研究。在情绪应激状态下，一些家兔的动脉血压几乎未变，心率仅略有增加，而另一些动物则表现出明显的血液循环紊乱，在实验末期导致急性心力衰竭。在抗应激的家兔中，神经元的显微解剖结构和超微结构表明其活性增强。溶酶体酶——酸性磷酸酶和氨肽酶的活性处于对照水平，而线粒体酶——谷氨酸脱氢酶的活性略有增加。另一方面，在易应激的家兔神经元中发现了严重活动亢进和衰竭的形态学证据。此外，所研究的这三种酶的活性均显著增加。这些结果表明，实验性情绪应激状态下结节神经节神经元发生的结构和代谢变化与血液动力学变化程度之间存在相关性。
