Enhancement of phorbol ester-induced production of tumor necrosis factor-alpha by 2,6-dimethylphenylphthalimide.
作者信息
Shibata Y, Sasaki K, Nishimura K, Hashimoto Y, Iwasaki S
机构信息
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
出版信息
Biol Pharm Bull. 1994 Nov;17(11):1532-4. doi: 10.1248/bpb.17.1532.
PMID:7703981
Abstract
The effect of phenyl- and benzylphthalimide analogs on tumor necrosis factor (TNF)-alpha production by a human leukemia cell line, HL-60, stimulated with 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was investigated. Though non-substituted phenyl- and benzyl-phthalimide had no effect on TNF-alpha production after TPA-induction, introduction of methyl group(s) onto the phenyl group resulted in the appearance of potent enhancing activity on TNF-alpha production.
摘要
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