Inducer-specific regulators of tumor necrosis factor alpha production.
作者信息
Miyachi H, Azuma A, Hioki E, Kobayashi Y, Iwasaki S, Hashimoto Y
机构信息
Institute of Molecular & Cellular Biosciences, University of Tokyo, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1996 Oct;44(10):1980-2. doi: 10.1248/cpb.44.1980.
PMID:8904830
Abstract
Novel potent regulators of tumor necrosis factor alpha (TNF-alpha) production by a human promyelocytic leukemia cell line, HL-60, were prepared. All the compounds showed inducer-specific and bidirectional regulation of TNF-alpha production, i.e., they enhanced 12-O-tetradecanoylphorbol-13-acetate-induced TNF-alpha production, while they inhibited okadaic acid-induced one.
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