日本格雷夫斯病患者的人类白细胞抗原（HLA）II类等位基因：HLA-DR和-DQ的弱关联

HLA class II alleles in Japanese patients with Graves' disease: weak associations of HLA-DR and -DQ.

作者信息

Katsuren E, Awata T, Matsumoto C, Yamamoto K

机构信息

Division of Endocrinology and Metabolism, Jichi Medical School, Tochigi, Japan.

出版信息

Endocr J. 1994 Dec;41(6):599-603. doi: 10.1507/endocrj.41.599.

DOI:10.1507/endocrj.41.599

PMID:7704083

Abstract

To elucidate the associations of the HLA class II alleles with Graves' disease (GD), we examined DRB1, DQA1, DQB1 alleles in 62 Japanese GD patients and 142 control subjects by the PCR-SSOP (polymerase chain reaction-sequence specific oligonucleotide probes) method. We found that DRB10803 (P < 0.02), DRB11403 (P < 0.03), DQA10103 (P < 0.02) alleles and DRB10803-DQA10103-DQB10601 (P < 0.01), DRB11403-DQA10501-DQB1*0301 (P < 0.02) haplotypes were significantly increased in GD patients. No DQB1 allele revealed a significant association with GD in Japanese. These weak associations may reflect either the heterogeneity of GD in Japanese or the importance of non-HLA factors in the development of the disease.

摘要

为阐明人类白细胞抗原（HLA）Ⅱ类等位基因与格雷夫斯病（GD）的关联，我们采用聚合酶链反应-序列特异性寡核苷酸探针（PCR-SSOP）方法，检测了62例日本GD患者和142例对照者的DRB1、DQA1、DQB1等位基因。我们发现，DRB10803（P < 0.02）、DRB11403（P < 0.03）、DQA10103（P < 0.02）等位基因以及DRB10803-DQA10103-DQB10601（P < 0.01）、DRB11403-DQA10501-DQB1*0301（P < 0.02）单倍型在GD患者中显著增加。在日本人中，未发现DQB1等位基因与GD有显著关联。这些微弱的关联可能反映了日本人GD的异质性，或者非HLA因素在该疾病发生中的重要性。