Höld K M, de Boer D, Zuidema J, Maes R A
Department of Analysis and Toxicology, Utrecht University, Netherlands.
J Chromatogr B Biomed Appl. 1995 Jan 6;663(1):103-10. doi: 10.1016/0378-4347(94)00431-4.
The Salivette was evaluated with a range of racemic beta-adrenoceptor blocking drugs with different lipophilicity. Recovery from the Salivette appeared to be independent of the stereochemical configuration of the drugs but a significant loss of drug due to the Salivette was observed for all tested drugs. The performance of the method, in terms of accuracy and precision, fitted well within the generally accepted criteria for validation, except near the limit of quantification. The Salivette is successfully used for quantitating salivary beta-blocking drugs.
使用一系列具有不同亲脂性的消旋β-肾上腺素能阻滞剂对唾液采集管进行了评估。唾液采集管的回收率似乎与药物的立体化学构型无关，但对于所有测试药物，均观察到唾液采集管导致药物有显著损失。该方法在准确性和精密度方面的表现，除了在定量限附近外，很好地符合了普遍接受的验证标准。唾液采集管已成功用于定量唾液中的β受体阻滞剂药物。
