中缝正中核5-羟色胺1A受体的激动剂激活与雌性大鼠脊柱前凸行为

Agonist activation of 5-HT1A receptors in the median raphe nucleus and female rat lordosis behavior.

作者信息

Uphouse L, Maswood S, Caldarola-Pastuszka M

机构信息

Department of Biology, Texas Woman's University, Denton 76204, USA.

出版信息

Brain Res. 1994 Dec 30;668(1-2):271-5. doi: 10.1016/0006-8993(94)90536-3.

DOI:10.1016/0006-8993(94)90536-3

PMID:7704614

Abstract

Proestrous rats were infused unilaterally into the median raphe nucleus with 200-2,000 ng of the 5-HT1A agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Inhibition of the lordosis to mount ratio occurred within 15 and 10 min, respectively, following infusion with 1,000 or 2,000 ng of the drug. Infusion of 2,000 ng of the 5-HT2 agonist, (+/-)-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCl (DOI), or 4,000 ng 5-HT (creatinine sulfate) failed to substantially reduce lordosis behavior.

摘要

将200 - 2000纳克的5 - HT1A激动剂8 - 羟基 - 2 -（二正丙基氨基）四氢萘（8 - OH - DPAT）单侧注入动情前期大鼠的中缝正中核。分别在注入1000纳克或2000纳克该药物后的15分钟和10分钟内，出现了对脊柱前凸与爬跨比例的抑制。注入2000纳克的5 - HT2激动剂（±） -（2,5 - 二甲氧基 - 4 - 碘苯基） - 2 - 氨基丙烷盐酸盐（DOI）或4000纳克5 - 羟色胺（硫酸肌酐）未能显著降低脊柱前凸行为。