重组猫干扰素（rFeIFN）对多种细胞的体外抗增殖和集落形成抑制活性。
Antiproliferation and colony-forming inhibition activities of recombinant feline interferon (rFeIFN) on various cells in vitro.
作者信息
Priosoeryanto B P, Tateyama S, Yamaguchi R, Uchida K
机构信息
Department of Veterinary Pathology, Faculty of Agriculture, Miyazaki University, Japan.
出版信息
Can J Vet Res. 1995 Jan;59(1):67-9.
The antiproliferative and colony inhibiting activities of recombinant feline interferon (rFeIFN Type I) against various cells in vitro were examined. Feline and canine cells were both sensitive to rFeIFN. To inhibit the growth of feline cells by 50% approximately 5 x 10(2) to 1 x 10(3) U/mL rFeIFN was required and maximum activity was achieved at a concentration of 1 x 10(5) U/mL. Approximately 5 x 10(3) to 5 x 10(4) U/mL rFeIFN was necessary to inhibit the growth of canine cells by 50%. The antiproliferative and colony inhibiting activities of rFeIFN on canine cells appeared to be cell-specific and dose-dependent. However, human, monkey and hamster cells were resistant to rFeIFN. We suggest that rFeIFN might be useful for treatment of feline and some canine neoplastic conditions.
检测了重组猫干扰素（I型重组猫干扰素，rFeIFN）在体外对各种细胞的抗增殖和集落抑制活性。猫和犬的细胞对rFeIFN均敏感。要使猫细胞的生长抑制50%，大约需要5×10²至1×10³ U/mL的rFeIFN，在浓度为1×10⁵ U/mL时达到最大活性。要使犬细胞的生长抑制50%，大约需要5×10³至5×10⁴ U/mL的rFeIFN。rFeIFN对犬细胞的抗增殖和集落抑制活性似乎具有细胞特异性且呈剂量依赖性。然而，人、猴和仓鼠细胞对rFeIFN具有抗性。我们认为rFeIFN可能对治疗猫和某些犬的肿瘤性疾病有用。
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