Personality factors and drug effects in a controlled study of cyclazocine.

This paper investigated the relationship between measurable personality factors and level of effects shown to cyclazocine and placebo in a controlled study. An attempt also was made through case analysis to examine the association between dynamic aspects of personality and adverse drug effect. Hysteria scores on the MMPI were found to be related significantly to self-reported effects under both the drug and placebo conditions. Clinical observations were examined retrospectively for three cases with adverse reactions and cited to support a dynamic theory that associated drug reactivity to personality factors.