Cadiot G, Hélie C, Vallot T, Marmuse J P, Cosnes J, Riché A, Mignon M
Service d'Hépato-Gastroentérologie, Hôpital Bichat-Claude-Bernard, Paris.
Gastroenterol Clin Biol. 1994;18(11):1018-20.
Three patients with the Zollinger-Ellison syndrome and severe oesophagitis are reported. Intractable oesophageal stricture developed, leading to oesophago-gastrectomy in two patients and iterative oesophageal dilatations in the third. The retrospective analysis of these 3 cases led us to recommend, in case of oesophagitis in patients who have or might have the Zollinger-Ellison syndrome, to quickly institute a major antisecretory treatment, by parenteral route if necessary, to precociously and repeatedly control the efficacy of the antisecretory treatment mainly by measuring basal acid output and to avoid unjustified treatment discontinuance and gastric intubations.
本文报告了3例患有卓-艾综合征及严重食管炎的患者。出现了难治性食管狭窄,导致2例患者接受了食管胃切除术,第3例患者接受了反复的食管扩张术。对这3例病例的回顾性分析使我们建议,对于患有或可能患有卓-艾综合征的患者出现食管炎时,应迅速开始大剂量抗分泌治疗,必要时采用胃肠外途径,主要通过测量基础胃酸分泌量来尽早并反复控制抗分泌治疗的效果,避免不合理地停用治疗及进行胃插管。