奥美拉唑与中枢神经系统活性药物在大鼠体内的药效学相互作用。
Pharmacodynamic interactions of omeprazole with CNS active drugs in rats.
作者信息
Chandrashekhar S M, Chakrabarti A, Garg S K
机构信息
Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh.
出版信息
Indian J Physiol Pharmacol. 1995 Jan;39(1):74-6.
A pharmacodynamic interactional study with omeprazole was undertaken in rats. Omeprazole (7 mg/kg, orally once daily for 14 days) significantly prolonged pentobarbitone (30 mg/kg, ip) induced hypnosis while it had no effect on haloperidol (1 mg/kg, ip) induced catalepsy or morphine (5 mg/kg, ip) induced analgesia models in rats. The study highlighted the fact that dynamic interaction with omeprazole was selective.
在大鼠中进行了奥美拉唑的药效学相互作用研究。奥美拉唑（7毫克/千克，口服，每日一次，共14天）显著延长了戊巴比妥（30毫克/千克，腹腔注射）诱导的催眠时间，而对氟哌啶醇（1毫克/千克，腹腔注射）诱导的僵住症或吗啡（5毫克/千克，腹腔注射）诱导的镇痛模型在大鼠中没有影响。该研究突出了与奥美拉唑的动态相互作用具有选择性这一事实。
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