Matsumoto K, Tanaka K, Matsutani S, Sakazaki R, Hinoo H, Uotani N, Tanimoto T, Kawamura Y, Nakamoto S, Yoshida T
Shinogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
J Antibiot (Tokyo). 1995 Feb;48(2):106-12. doi: 10.7164/antibiotics.48.106.
Thielocins A2 alpha, A2 beta, A3, B1, B2 and B3 were isolated as a novel family of phospholipase A2 inhibitors from the fermentation broth of Thielavia terricola RF-143 together with thielavins and thielocins A1 alpha and A1 beta. The most potent inhibitory activity (IC50 = 0.0033 microM) against rat group II phospholipase A2 was shown by thielocin A1 beta. Against human group II phospholipase A2, thielocin B3 (IC50 = 0.076 microM) was the most potent.
从土栖嗜热放线菌RF-143的发酵液中分离出了嗜热放线菌素A2α、A2β、A3、B1、B2和B3，它们是一类新型的磷脂酶A2抑制剂，同时还分离出了嗜热菌素和嗜热放线菌素A1α及A1β。嗜热放线菌素A1β对大鼠II型磷脂酶A2显示出最强的抑制活性（IC50 = 0.0033微摩尔）。对于人II型磷脂酶A2，嗜热放线菌素B3（IC50 = 0.076微摩尔）的抑制作用最强。
