Moon J
National College of Naturopathic Medicine, Portland Oregon 97216.
J Am Coll Nutr. 1994 Dec;13(6):559-64. doi: 10.1080/07315724.1994.10718447.
Vitamin D increases intestinal calcium and phosphate absorption. Not so well known, however, is that vitamin D stimulates the co-absorption of other essential minerals like magnesium, iron, and zinc; toxic metals including lead, cadmium, aluminum, and cobalt; and radioactive isotopes such as strontium and cesium. Vitamin D may contribute to the pathologies induced by toxic metals by increasing their absorption and retention. Reciprocally, lead, cadmium, aluminum, and strontium interfere with normal vitamin D metabolism by blocking renal synthesis of 1,25-dihydroxyvitamin D. This is the first review of the role of the vitamin D endocrine system in metal toxicology.
维生素D可增加肠道对钙和磷的吸收。然而，鲜为人知的是，维生素D会刺激其他必需矿物质（如镁、铁和锌）、有毒金属（包括铅、镉、铝和钴）以及放射性同位素（如锶和铯）的共同吸收。维生素D可能通过增加有毒金属的吸收和潴留而导致由其引发的病理状况。相反，铅、镉、铝和锶会通过阻断肾脏合成1,25-二羟基维生素D来干扰正常的维生素D代谢。这是首篇关于维生素D内分泌系统在金属毒理学中作用的综述。
