Volkova N A, Karpliuk I A
Vopr Pitan. 1993 Oct-Dec(5):53-7.
The role of vitamin D in regulation of phosphoric-calcium metabolism was evaluated in conditions of experimental cadmium intoxication induced by daily dietetic intake (100 micrograms/kg for 8 months) of cadmium in parallel with intake of calcium in diverse amounts. Daily requirements in vitamin D were provided in different groups of animals either with ergocalciferol (D2) or 24,25-dihydroxycholecalciferol (0.25 microgram per animal). The results of the trial suggested that despite regular supply of ergocalciferol, renal damage induced by cadmium intoxication was associated with phosphoric-calcium metabolic derangement which is likely to result from defects in renal synthesis of active vitamin D form. This was confirmed by the fact that the change of ergocalciferol for 24,25-dihydroxycholecalciferol did not produce any noticeable shifts in the phosphoric-calcium metabolism.
在通过每日饮食摄入镉（100微克/千克，持续8个月）诱导实验性镉中毒的条件下，同时给予不同量的钙，评估了维生素D在调节磷钙代谢中的作用。不同组动物的维生素D每日需求量通过给予麦角钙化醇（D2）或24,25-二羟胆钙化醇（每只动物0.25微克）来满足。试验结果表明，尽管定期供应麦角钙化醇，但镉中毒引起的肾损伤与磷钙代谢紊乱有关，这可能是由于活性维生素D形式的肾合成缺陷所致。用24,25-二羟胆钙化醇替代麦角钙化醇后，磷钙代谢没有出现任何明显变化，这一事实证实了上述观点。
