从凋亡的人T细胞系中克隆一种与NGFI-B/nur77相关的转录因子的cDNA
cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line.
作者信息
Okabe T, Takayanagi R, Imasaki K, Haji M, Nawata H, Watanabe T
机构信息
Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
出版信息
J Immunol. 1995 Apr 15;154(8):3871-9.
A human T lymphoid cell line, PEER, dies by apoptosis in the presence of PMA and calcium ionophore. A new gene, TINUR, was cloned from apoptotic PEER cells. The expression of the TINUR gene is induced within 1 h after the cross-linking of the T cell Ag receptor complex. TINUR belongs to the NGFI-B/nur77 family of the steroid receptor superfamily and is an orphan receptor. TINUR binds to the same DNA sequence as NGFI-B/nur77. We also propose that the NGFI-B/nur77 family can be classified into two subtypes.
一种人类T淋巴细胞系PEER，在佛波酯（PMA）和钙离子载体存在的情况下会通过凋亡死亡。从凋亡的PEER细胞中克隆出了一个新基因TINUR。TINUR基因的表达在T细胞抗原受体复合物交联后1小时内被诱导。TINUR属于类固醇受体超家族的NGFI-B/nur77家族，是一种孤儿受体。TINUR与NGFI-B/nur77结合相同的DNA序列。我们还提出NGFI-B/nur77家族可分为两个亚型。
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