Altamirano M, Delaney A, Wong A, Marostenmaki J, Pi D
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.
J Infect Dis. 1995 Apr;171(4):1034-8. doi: 10.1093/infdis/171.4.1034.
The distribution pattern of hepatitis C virus (HCV) genotypes among patients from British Columbia has been investigated by reverse transcription polymerase chain reaction (PCR) amplification of the 5' noncoding region (NCR) and direct DNA sequencing of the PCR product. The sequence data obtained from the British Columbia isolates were compared with HCV sequences for the NCR obtained from GenBank for the construction of a phylogenetic tree using the GDE program, version 2.2. The data show that in British Columbia there are 7 subtypes distributed among major genotypes 1, 2, and 3. The study also shows a new subtype of genotype 1 that represents 29% of the analyzed cases.
