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用于筛选局部用驱蚊剂的实验室小鼠模型的评估

Evaluation of the laboratory mouse model for screening topical mosquito repellents.

作者信息

Rutledge L C, Gupta R K, Wirtz R A, Buescher M D

机构信息

U.S. Army Research, Development, Acquisition and Logistics Command, Fort Detrick, Frederick, MD 21702-5012, USA.

出版信息

J Am Mosq Control Assoc. 1994 Dec;10(4):565-71.

PMID:7707065
Abstract

Eight commercial repellents were tested against Aedes aegypti 0 and 4 h after application in serial dilution to volunteers and laboratory mice. Results were analyzed by multiple regression of percentage of biting (probit scale) on dose (logarithmic scale) and time. Empirical correction terms for conversion of values obtained in tests on mice to values expected in tests on human volunteers were calculated from data obtained on 4 repellents and evaluated with data obtained on 4 others. Corrected values from tests on mice did not differ significantly from values obtained in tests on volunteers. Test materials used in the study were dimethyl phthalate, butopyronoxyl, butoxy polypropylene glycol, MGK Repellent 11, deet, ethyl hexanediol, Citronyl, and dibutyl phthalate.

摘要

对8种商用驱虫剂进行了测试,在将其按系列稀释后涂抹于志愿者和实验小鼠身上0小时和4小时后,检测其对埃及伊蚊的驱避效果。通过对叮咬百分比(概率尺度)与剂量(对数尺度)和时间进行多元回归分析结果。根据4种驱虫剂的测试数据计算出将小鼠测试所得值转换为人类志愿者测试预期值的经验校正项,并用另外4种驱虫剂的数据进行评估。小鼠测试的校正值与志愿者测试所得值无显著差异。该研究中使用的测试材料有邻苯二甲酸二甲酯、丁氧丙二醇、丁氧基聚丙二醇、MGK驱虫剂11、避蚊胺、己二醇、香茅醇和邻苯二甲酸二丁酯。

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Use of a semi-field system to evaluate the efficacy of topical repellents under user conditions provides a disease exposure free technique comparable with field data.使用半野外系统在用户条件下评估局部驱避剂的功效,提供了一种与野外数据相当的无疾病暴露技术。
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Reproductive toxicity of di-n-butylphthalate in a continuous breeding protocol in Sprague-Dawley rats.
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