Clement D L, De Buyzere M, Duprez D D
University Hospital, Department of Cardiovascular Diseases, Gent, Belgium.
J Hypertens Suppl. 1994 Nov;12(8):S49-53.
To study the causes of blood pressure variability by using antihypertensive drugs.
Survey of published studies.
The results are sometimes unclear and, for some drugs, contradictory. beta-Adrenoceptor antagonists appear to have no effect on blood pressure variability, whereas alpha-adrenoceptor antagonists and atropine can lessen the amplitude of the variations. Similarly, there is a decrease after the administration of clonidine. Guanfacine, however, which acts on the same central receptors, does not lessen variability. Calcium antagonists do not influence blood pressure variability and the results with angiotensin converting enzyme inhibitors are contradictory.
From these results we conclude that blood pressure variability is not dependent on beta-receptor activity or calcium-mediated mechanisms. It is most likely that both alpha-adrenergic tone and the vagal system have significant effects on blood pressure variability.
通过使用抗高血压药物研究血压变异性的原因。
对已发表研究进行调查。
结果有时不明确，且对于某些药物而言相互矛盾。β-肾上腺素受体拮抗剂似乎对血压变异性无影响，而α-肾上腺素受体拮抗剂和阿托品可减小变异幅度。同样，服用可乐定后变异幅度会降低。然而，作用于相同中枢受体的胍法辛却不会减小变异性。钙拮抗剂不影响血压变异性，血管紧张素转换酶抑制剂的结果相互矛盾。
从这些结果我们得出结论，血压变异性不依赖于β受体活性或钙介导机制。很可能α-肾上腺素能张力和迷走神经系统对血压变异性均有显著影响。
