Huang C K, Chen G H, Wahn J R, Nain H M, Cheng Y P, Chang C S, Liu J H, Ho K S
Department of Internal Medicine, Taichung Veterans General Hospital, Taiwan, Republic of China.
Gaoxiong Yi Xue Ke Xue Za Zhi. 1995 Feb;11(2):62-8.
Erythromycin has been shown to act on motilin receptors on gastrointestinal smooth muscle in vitro and to accelerate gastric emptying in normal subjects as well as in patients with diabetic mellitus. To evaluate the motor pattern that accounts for this accelerated emptying, the effects of 12.5 mg/min erythromycin vs. placebo on postprandial motility of the antroduodenum was examined with real-time ultrasound in 15 normal subjects. During 10 minutes of observation, erythromycin significantly increased forward transpyloric flow episode (1.04 +/- 0.19 vs. 0.37 +/- 0.41; p < 0.05), forward transpyloric flow duration (5.79 < 4.49 vs. 3.19 < 1.72 seconds; p < 0.05) and improved antro-pyloro-duodenal coordination (0.43 +/- 0.23 vs. 0.21 +/- 0.17; p < 0.05). However, no significant differences were found for gastric peristaltic cycle (22.62 +/- 3.06 vs. 23.40 +/- 2.14 seconds; p > 0.05), retrograde transpyloric flow episode (0.13 +/- 0.16 vs. 0.18 +/- 0.29; p > 0.05), and retrograde transpyloric flow duration (1.24 +/- 0.30 vs. 1.38 +/- 0.58 seconds; p > 0.05). We conclude that erythromycin increases episode and duration of forward transpyloric flow, and improves antro-pyloro-duodenal coordination, which may play a role in accelerating gastric emptying.
体外实验表明，红霉素作用于胃肠道平滑肌的胃动素受体，可加速正常人和糖尿病患者的胃排空。为评估导致胃排空加速的运动模式，采用实时超声检查了15名正常受试者在餐后服用12.5mg/min红霉素与安慰剂后胃十二指肠的运动情况。在10分钟的观察期内，红霉素显著增加了正向经幽门流动次数（1.04±0.19比0.37±0.41；p<0.05）、正向经幽门流动持续时间（5.79<4.49比3.19<1.72秒；p<0.05），并改善了胃幽门十二指肠协调性（0.43±0.23比0.21±0.17；p<0.05）。然而，胃蠕动周期（22.62±3.06比23.40±2.14秒；p>0.05）、逆向经幽门流动次数（0.13±0.16比0.18±0.29；p>0.05）和逆向经幽门流动持续时间（1.24±0.30比1.38±0.58秒；p>0.05）未发现显著差异。我们得出结论，红霉素增加了正向经幽门流动的次数和持续时间，并改善了胃幽门十二指肠协调性，这可能在加速胃排空中发挥作用。
