King P M, Pryde A, Heading R C
Gut. 1987 May;28(5):545-8. doi: 10.1136/gut.28.5.545.
The pattern of transpyloric fluid movement and associated antroduodenal motility was compared in patients with gastro-oesophageal reflux (GOR) and healthy controls using real time ultrasonic imaging. A similar number of cyclical periods of antroduodenal motor activity (GOR 94 and control 91) was studied in each group. Mean antral cycle times and the frequency of occurrence of related proximal duodenal contractions (antroduodenal coordination) were similar. Transpyloric fluid movement occurred as a number of discrete episodes in each cycle. Gastroduodenal flow was more frequent in the GOR group (mean 2.7 +/- 0.4 episodes per cycle) than in controls (mean 1.7 +/- 0.3). The mean duration of these episodes in both groups was similar at around 2.5 seconds. Duodenogastric flow (reflux) was observed in many cycles (GOR 63%; controls 54%), but there was no difference in the mean number of episodes per cycle (GOR 0.79; control 0.74) or their mean duration (two seconds for both). Transpyloric fluid flow only occurs when a pressure gradient is created across the open pylorus. These observations indicate that in GOR the gastroduodenal pressure gradient is positive more frequently than in normal controls. Gastroduodenal liquid flow but not duodenogastric reflux differs in GOR patients and controls.
采用实时超声成像技术,对胃食管反流(GOR)患者和健康对照者的经幽门液体流动模式及相关的十二指肠运动进行了比较。每组研究的十二指肠运动活动的周期性次数相近(GOR组94次,对照组91次)。平均胃窦周期时间以及相关近端十二指肠收缩的发生频率(胃窦十二指肠协调性)相似。经幽门液体流动在每个周期中表现为多个离散的事件。GOR组的胃十二指肠流动比对照组更频繁(平均每个周期2.7±0.4次事件)(对照组为平均1.7±0.3次)。两组中这些事件的平均持续时间相似,约为2.5秒。在许多周期中观察到十二指肠胃反流(反流)(GOR组63%;对照组54%),但每个周期的平均事件次数(GOR组0.79;对照组0.74)或其平均持续时间(两组均为2秒)没有差异。经幽门液体流动仅在开放的幽门处形成压力梯度时才会发生。这些观察结果表明,与正常对照组相比,GOR患者胃十二指肠压力梯度为正的频率更高。GOR患者和对照组在胃十二指肠液体流动方面存在差异,但在十二指肠胃反流方面没有差异。