Whelan G, Flecknell P A
Comparative Biology Centre, University of Newcastle upon Tyne, Medical School, UK.
Lab Anim. 1995 Jan;29(1):83-9. doi: 10.1258/002367795780740384.
The use of etorphine (a potent mu-opioid), methotrimeprazine (a phenothiazine tranquilizer) and midazolam (a benzodiazepine) in laboratory rabbits is described. The central ear artery was cannulated under local anaesthesia using lignocaine/prilocaine cream, enabling cardiovascular monitoring in conscious animals. Anaesthesia was characterized by respiratory arrest, profound analgesia and a stable cardiovascular system (after commencing intermittent positive pressure ventilation). Reversal of anaesthesia with buprenorphine (a partial mu agonist) did not reduce the degree of post-operative respiratory depression, but shortened the period of unconsciousness considerably. This anesthetic regimen can only be recommended for rabbits that are free of respiratory disease and if facilities for IPPV are available.
本文描述了依托啡烷（一种强效μ阿片类药物）、甲氧异丁嗪（一种吩噻嗪类镇静剂）和咪达唑仑（一种苯二氮䓬类药物）在实验兔中的使用情况。使用利多卡因/丙胺卡因乳膏在局部麻醉下对兔中耳中央动脉进行插管，以便在清醒动物中进行心血管监测。麻醉的特征为呼吸停止、深度镇痛和稳定的心血管系统（在开始间歇性正压通气后）。使用丁丙诺啡（一种部分μ激动剂）进行麻醉苏醒，并未降低术后呼吸抑制的程度，但显著缩短了无意识期。这种麻醉方案仅适用于无呼吸系统疾病且具备间歇性正压通气设备的兔。
